Jeffrey Apfelbaum, M.D.

Professor of Anesthesia & Critical Care
Chairman

(773) 702-2545

Training

B.A. - 1970 - 1974
Swarthmore College - Swarthmore, Pennsylvania USA - Biochemistry

M.D. - 1974 - 1978
Northwestern University School of Medicine - Chicago, Illinois USA

Internship - 1978 - 1979
Hahneman Medical College and Hospital - Philadelphia, Pennsylvania USA - Medicine

Residency - 1979 - 1981
University of Pennsylvania School of Medicine - Philadelphia, Pennsylvania USA - Anesthesia

Fellowship - 1982 - 1983
University of Pennsylvania School of Medicine - Philadelphia, Pennsylvania USA - Anesthesia

Clinical Interests

Ambulatory Anesthesia
Recovery from Sedative Hypnotics

Academic Interests

Ambulatory Anesthesia
Recovery from Sedative Hypnotics

Recent Publications

Apfelbaum JL, Silverstein JH, Chung FF, Connis RT, Fillmore RB, Hunt SE, Nickinovich DG, Schreiner MS, Silverstein JH, Apfelbaum JL, Barlow JC, Chung FF, Connis RT, Fillmore RB, Hunt SE, Joas TA, Nickinovich DG, Schreiner MS: Practice guidelines for ostanesthetic care: an updated report by the American Society of Anesthesiologists Task Force on Postanesthetic Care. Anesthesiolog; Feb;118(2):291-307, 2013.

Apfelbaum JL, Schreiner MS, Silverstein JH, Apfelbaum JL, Barlow JC, Chung FF, Connis RT, Fillmore RB, Hunt SE, Joas TA, Nickinovich DG, Schreiner MS: Practice Guidelines For Postanesthetic Care: An Updated Report By The American Society Of Anesthesiologists Task Force On Postanesthetic Care. Anesthesiology. Feb;118(2):291-307. 2013.

Apfelbaum JL, Hagberg CA, Caplan RA, Blitt CD, Connis RT, Nickinovich DG, Hagberg CA, Caplan RA, Benumof JL, Berry FA, Blitt CD, Bode RH, Cheney FW, Connis RT, Guidry OF, Nickinovich DG, Ovassapian A: Practice Guidelines For Management Of The Difficult Airway: An Updated Report By The American Society Of Anesthesiologists Task Force On Management Of The Difficult Airway. Anesthesiology. Feb;118(2):251-70., 2013.

Apfelbaum JL, Connis RT, Nickinovich DG: 2012 Emery A. Rovenstine Memorial Lecture: The Genesis, Development, and Future of the American Society of Anesthesiologists Evidence-based Practice Parameters. Anesthesiology. 2013 Apr;118(4):767-8., 2013.

Apfelbaum JL, Caplan RA, Barker SJ, Connis RT, Cowles C, Ehrenwerth J, Nickinovich DG, Pritchard D, Roberson DW, Caplan RA, Barker SJ, Connis RT, Cowles C, de Richemond AL, Ehrenwerth J, Nickinovich DG, Pritchard D, Roberson DW, Wolf GL: Practice advisory for the prevention and management of operating room fires: an updated report by the American Society of Anesthesiologists Task Force on Operating Room Fires. Anesthesiology. Feb;118(2):271-90. 2013.

Ashburn MA, Apfelbaum JL, Connis RT, Nickinovich DG: In reply. Anesthesiology. Dec;117(6):1398. 2012.

American Society of Anesthesiologists Task Force on Central Venous Access, Rupp SM, Apfelbaum JL, Blitt C, Caplan RA, Connis RT, Domino KB, Fleisher LA, Grant S, Mark JB, Morray JP, Nickinovich DG, Tung A.: Practice guidelines for central venous access: a report by the American Society of Anesthesiologists Task Force on Central Venous Access. Anesthesiology. Mar;116(3):539-73, 2012.

Committee on Standards and Practice Parameters, Apfelbaum JL, Connis RT, Nickinovich DG; American Society of Anesthesiologists Task Force on Preanesthesia Evaluation, Pasternak LR, Arens JF, Caplan RA, Connis RT, Fleisher LA, Flowerdew R, Gold BS, Mayhew JF, Nickinovich DG, Rice LJ, Roizen MF, Twersky RS: Practice Advisory For Preanesthesia Evaluation: An Updated Report By The American Society Of Anesthesiologists Task Force On Preanesthesia Evaluation. Anesthesiology. Mar;116(3):522-38, 2012.

American Society of Anesthesiologists Task Force on Perioperative Visual Loss: Practice Advisory For Perioperative Visual Loss Associated With Spine Surgery: An Updated Report By The American Society Of Anesthesiologists Task Force On Perioperative Visual Loss. Anesthesiology. Feb;116(2):274-85. 2012.

American Society of Anesthesiologists Task Force on Acute Pain Management:  Anesthesiology. Practice Guidelines For Acute Pain Management In The Perioperative Setting: An Updated Report By The American Society Of Anesthesiologists Task Force On Acute Pain Management. Feb;116(2):248-73., 2012.

Xie Z, Hussain W, Cutter TW, Apfelbaum JL, Drum ML, Manning DW: Three-In-One Nerve Block With Different Concentrations Of Bupivacaine In Total Knee Arthroplasty: Randomized, Placebo-Controlled, Double-Blind Trial. J Arthroplasty.  May;27(5):673-8.e1. Epub 2011 Sep 23. 2012.

Apfelbaum JL, Connis RT, Caplan RA, Nickinovich DG, Warner MA: Practice Advisory for the Prevention of Perioperative Peripheral Neuropathies. Anesthesiology; 114(4):741-754,  2011

Apfelbaum JL, Caplan RA, Connis RT, Epstein, BS, Nickinovich DG, Warner, MA: Practice Guidelines for Preoperative Fasting and the Use of Pharmacologic Agents to Reduce the Risk of Pulmonary Aspiration: Application to Healthy Patients Undergoing Elective Procedures. Anesthesiology; 114(3):495-511 2011

Zaidan JR, Apfelbaum JL, Belott P, Connis RT, Nickinovich DG, Rozner MA: Practice Advisory for the Perioperative Management of Patients with Cardiac Implantable Electronic Devices: Pacemakers and Implantable Cardioverter-Defibrillators. Anesthesiology; 114(2):247-261 2011

Apfelbaum JL, Desjardins PJ, Brown MT, Verburg KM. Multiple-day Efficacy of Parecoxib Sodium Treatment in Postoperative Bunionectomy Pain. Clin J Pain 2008; 24:784–792

Apfelbaum JL, Desjardins PJ, Brown MT, Verburg KM. Multiple-day Efficacy of Parecoxib Sodium Treatment in Postoperative Bunionectomy Pain. Clin J Pain 2008; 24:784–792

Apfelbaum JL, Desjardins PJ, Brown MT, Verburg KM. Multiple-day Efficacy of Parecoxib Sodium Treatment in Postoperative Bunionectomy Pain. Clin J Pain 2011; 24:784–792

Abouleish AE. Apfelbaum JL. Prough DS. Williams JP. Roskoph JA. Johnston WE. Whitten CW. The prevalence and characteristics of incentive plans for clinical productivity among academic anesthesiology programs. [see comment]. [Journal Article] Anesth Analg 2005; 100(2):493-501.

Apfelbaum JL, Gan TJ, Zhao S, Hann DB, Chen C. Reliability and Validity of the Perioperative Opioid-Related Symptom Distress Scale. Anesth Analg 2004; 99:699-709

Apfelbaum JL, Chen C, Mehta SS, Gan TJ. Postoperative Pain Experience: Results from a national survey suggest postoperative pain continues to be under managed. Anesth Analg 2003; 97:534-40.

Abouleish A.E., Prough DS, Barker SJ, Whitten CW, Uchida T, Apfelbaum JL. Organizational Factors Affect Comparisons of Clinical Productivity of Academic Anesthesiology Departments. Anesth Analg 96: 802-812; 2003

Apfelbaum JL, Walawander CA, Grasela TH, Wise P, McLeskey C, Roizen MF, Wetchler BV, Corttila K: Eliminating Intensive Postoperative Care in Same Day Surgery Patients Using Short Acting Anesthetics. Anesthesiology 97:66-74, 2002

Silverstein JH, Apfelbaum JL, Barlow JC, Chung FF, Connis RT, Fillmore RB, Hunt SE, Joas TA, Nickinovich DG, Schreiner MS: American Society of Anesthesiologists Task Force on Postanesthesia Care: Practice guidelines for post anesthetic care: a report by the American Society of Anesthesiologists Task Force on Postanesthetic Care. Anesthesiology 96:742-752, 2002

O’Connor MF, Daves SM, Tung A, Cook RI, Thisted RA, Apfelbaum JL: BIS monitoring to prevent awareness during general anesthesia. Anesthesiology 94:520-522, 2001

Apfelbaum JL, O’Connor MF: Update on transfusion therapy. Semin Cardiothorac Vasc Anesth 4:236-243, 2000

Conley KM, Toledano AY, Apfelbaum JL, Zacny JP: Modulating effects of a cold water stimulus on opioid effects in volunteers. Psychopharmacology 131:313-320, 1997

Young CJ, Coalson D, Klock PA, Klafta JM, Goldsher G, Apfelbaum JL, Zacny JP: Analgesic and psychomotor effects of thiopental at subanesthetic concentrations in human volunteers. Acta Anaesthesiol Scand 41:903-910, 1997

Galinkin JL, Janiszewski D, Young CJ, Klafta JM, Klock PA, Coalson DW, Apfelbaum JL, Zacny JP: Subjective, psychomotor, cognitive, and analgesic effects of subanesthetic concentrations of sevoflurane and nitrous oxide. Anesthesiology 87:1082-1088, 1997

Cho AM, Coalson DW, Klock PA, Klafta JM, Marks S, Toledano AY, Apfelbaum JL, Zacny JP: The effects of alcohol history on the reinforcing, subjective and psychomotor effects of nitrous oxide in healthy volunteers. Drug Alcohol Depend 45:63-70, 1997

Zacny JP, Lichtor JL, Coalson DW, Alessi R, Goldsher G, Young CJ, Apfelbaum JL, Conley KM: Examining the subjective, psychomotor and reinforcing effects of nitrous oxide in healthy volunteers: a dose-response analysis. Behav Pharmacol 7:194-199, 1996

Zacny JP, Coalson DW, Klafta JM, Klock PA, Alessi R, Rupani G, Young CJ, Patil PG, Apfelbaum JL: Midazolam does not influence intravenous fentanyl-induced analgesia in healthy volunteers. Pharmacol Biochem Behav 55:275-280, 1996

Zacny JP, Klafta JM, Coalson DW, Marks S, Young CJ, Kock PA, Toledano AY, Jordan N, Apfelbaum JL: The reinforcing effects of brief exposures to nitrous oxide in healthy volunteers. Drug Alcohol Depend 42:197-200, 1996

Zacny JP, Yajnik S, Lichtor JL, Klafta JM, Young CJ, Thapar P, Rupani G, Coalson DW, Apfelbaum JL: The acute residual effects of subanesthetic concentrations of isoflurane/nitrous oxide combinations on cognitive and pyschomotor performance in healthy volunteers. Anesth Analg 82:153-157, 1996

Zacny JP, Lichtor JL, Klafta JM, Alessi R, Apfelbaum JL: The effects of transnasal butorphanol on mood and psychomotor functioning in healthy volunteers. Anesth Analg 82:931-935, 1996

Zacny JP, McKay MA, Toledano AY, Marks S, Young CJ, Klock PA, Apfelbaum JL: The effects of a cold-water immersion stressor on the reinforcing and subjective effects of fentanyl in healthy volunteers. Drug Alcohol Depend 42:133-142, 1996

Zacny JP, Coalson DW, Young CJ, Klafta JM, Lichtor JL, Rupani G, Thapar P, Apfelbaum JL: Propofol at conscious sedation doses produces mild analgesia to cold pressor-induced pain in healthy volunteers. J Clin Anesth 8:469-474, 1996

Yajnik S, Zacny JP, Young CJ, Lichtor JL, Rupani G, Klafta JM, Coalson DW, Apfelbaum JL: Lack of acute tolerance development to the subjective, cognitive, and psychomotor effects of nitrous oxide in healthy volunteers. Pharmacol Biochem Behav 54:501-508, 1996

Apfelbaum JL, Lichtor JL, Lane BS, Coalson DW, Korttila KT: Awakening, clinical recovery, and psychomotor effects after desflurane and propofol anesthesia. Anesth Analg 83:721-725, 1996

Young CJ, Apfelbaum JL. Adult clinical experience with sevoflurane and pharmaco-economic aspects. Acta Anaesthesiol Belg 47:29-42, 1996

Zacny JP, Cho AM, Coalson DW, Rupani G, Young CJ, Klafta JM, Klock PA, Apfelbaum JL: Differential acute tolerance development to effects of nitrous oxide in humans. Neurosci Lett 209:73-76, 1996

Young CJ, Apfelbaum JL: Inhalational anesthetics: desflurane and sevoflurane. J Clin Anesth 7:564-577,

Apfelbaum JL: Mivacurium chloride administration by infusion. Acta Anaesthesiol Scand Suppl 106:55-57, 1995

Young CJ, Apfelbaum JL: Pharmacology of outpatient anesthesia in the year 2000. Acta Anaesthesiol Scand 39 (Suppl 105):75-83, 1995

Thapar P, Zacny JP, Choi M, Apfelbaum JL: Objective and subjective impairment from often-used sedative combinations in ambulatory surgery, using alcohol as a benchmark. Anesth Analg 80:1092-1098, 1995

Zacny JP, Yajnik S, Coalson D, Lichtor JL, Thapar P, Apfelbaum JL, Rupani G, Young C, Klafta J: Flumazenil may attenuate some subjective effects of nitrous oxide in humans: a preliminary report. Pharmacol Biochem Behav 51:815-819, 1995

Pirec V, Patterson TH, Thapar P Apfelbaum JL, Zacny JP: Effects of sub anesthetic concentrations of nitrous oxide on cold-pressor pain in humans. Pharmacol Biochem Behav 51:323-329, 1995

Pirec V, Coalson DW, Lichtor JL, Klafta J, Young C, Rupani G, Apfelbaum JL, Zacny JP: Cold water immersion modulates the reinforcing effects of nitrous oxide in healthy volunteers. Exp Clin Psychopharmacol 3:148-155, 1995

Thapar P, Zacny JP, Thompson W, Apfelbaum JL: Using alcohol as a metric to compare recovery profiles of often-used sedative agents in ambulatory surgery. Anesthesiology 82:53-59, 1995

Zacny JP, Coalson D, Young C, Klafta J, Rupani G, Thapar P, Choi M, Apfelbaum JL: A dose-response study of the effects of intravenous midazolam on cold pressor-induced pain. Anesth Analg 80:521-525, 1995

Thapar P, Korttila KT, Apfelbaum JL: Assessing recovery after day-case surgery. Curr Anaesth Crit Care 5:155-159, 1994

Zacny JP, Lichtor JL, Coalson DW, Flemming D, Apfelbaum JL, Foster V: Time course of effects of brief inhalations of nitrous oxide in normal volunteers. Addiction 89:831-839, 1994

Zacny JP, Lichtor JL, Thompson W, Apfelbaum JL: Propofol at a sub anesthetic dose may have abuse potential in healthy volunteers. Anesth Analg 77:544-552, 1993

White PF, Stanley TH, Apfelbaum JL, Grasela TH, Hug CC Jr, McLeskey CH, Nahrwold ML, Roizen MF, Thisted RA, Walawander CA: Effects on recovery when isoflurane is used to supplement propofol-nitrous oxide anesthesia. Anesth Analg 77:S15-S20, 1993

Scuderi P, Wetchler B, Sung YF, Mingus M, DePen S, Clayton L, Leslie J, Talke P, Apfelbaum JL, Sharifi-Azad S, Williams MF: Treatment of postoperative nausea and vomiting after outpatient surgery with the 5HT3 antagonist ondansetron. Anesthesiology 78:15-20, 1993

Zacny JP, Lichtor, JL, Zaragoza JG, Apfelbaum JL: The effects of a 5-HT3 antagonist, ondansetron, on cigarette smoking, smoke exposure and mood in humans. Pharmacol Biochem Behav 44:387-391, 1993

Lichtor JL, Zacny JP, Coalson DW, Flemming DC, Uitvlugt A, Apfelbaum JL, Lane BS, Thisted RA: The interaction between alcohol and the residual effects of thiopental anesthesia. Anesthesiology 79:28-35, 1993

Roizen MF, Stanley TH, Thisted RA, Walawander CA, White PF, Apfelbaum JL, Grasela TH, Hug CC Jr, McLeskey CH, Nahrwold ML: How do anesthesiologists select patients when introducing a new drug into practice? Anesth Analg 77:S30-S33, 1993

Nahrwold ML, Roizen MF, Stanley TH, Thisted RA, Walawander CA, White PF, Apfelbaum JL, Grasela TH, Hug CC Jr, McLeskey CH: Phase IV study of propofol: Validation of the data set. Anesth Analg 77:S34-S43, 1993

McLeskey CH, Walawander CA, Nahrwold ML, Roizen MF, Stanley TH, Thisted RA, White PF, Apfelbaum JL, Grasela TH, Hug CC Jr: Adverse events in a multicenter phase IV study of propofol: Evaluation by anesthesiologists and postanesthesia care unit nurses. Anesth Analg 77:S3-S9, 1993

Hug CC Jr, McLeskey CH, Nahrwold ML, Roizen MF, Stanley TH, Thisted RA, Walawander CA, White PF, Apfelbaum JL, Grasela TH: Hemodynamic effects of propofol: Data from over 25,000 patients. Anesth Analg 77:S21-S29, 1993

Grasela TH, Watkins WD, Hug CC Jr, McLeskey CH, Nahrwold ML, Roizen MF, Stanley TH, Thisted RA, Walawander CA, White PF, Apfelbaum JL: The role of pharmacoepidemiology research in postmarketing surveillance and anesthesia practice/critical care medicine. Anesth Analg 77:S44-S50, 1993

Apfelbaum JL, Grasela TH, Hug CC Jr, McLeskey CH, Nahrwold ML, Roizen MF, Stanley TH, Thisted RA, Walawander CA, White PF: The initial clinical experience of 1819 physicians in maintaining anesthesia with propofol: Characteristics associated with prolonged time to awakening. Anesth Analg 77:S10-S14, 1993

Zacny JP, Lichtor JL, Zaragoza JG, Coalson DW, Uitvlugt AM, Flemming DC, Binstock WB, Cutter T, Apfelbaum JL: Assessing the abuse potential of propofol bolus injections in healthy volunteers. Drug Alcohol Depend 32:45-57, 1993

Apfelbaum JL, Kallar SK, Wetchler B: Muscle relaxants for outpatient surgery: old and new. J Clin Anesth 4:2S-8S, 1992

Apfelbaum JL, Glosten B: Preoperative laboratory screening tests. Curr Surg 49:22-27, 1992

Roizen MF, Coalson D, Hayward RSA, Schmittner J, Thisted RA, Apfelbaum JL, Stocking CB, Cassel CK, Pompei P, Ford DE, Steinberg EP: Can patients use an automated questionnaire to define their current health status? Med Care 30:MS74-MS84, 1992

Apfelbaum JL: Mivacurium infusion. J Drug Dev S2:21-24, 1992

Lichtor JL, Zacny J, Apfelbaum JL, Lane BS, Rupani G, Thisted RA, Dohrn C, Korttila K: Alcohol after sedation with I.V. midazolam-fentanyl: effects on psychomotor functioning. Br J Anaesth 67:579-584, 1992

Zacny JP, Lichtor JL, Coalson DW, Finn RS, Uitvlugt AM, Glosten B, Flemming DC, Apfelbaum JL: Subjective and psychomotor effects of subanesthetic doses of propofol in healthy volunteers. Anesthesiology 76:696-702, 1992

Korttila K, Nuotto EJ, Lichtor JL, Östman PL, Apfelbaum J, Rupani G: Clinical recovery and psychomotor function after brief anesthesia with propofol or thiopental. Anesthesiology 76:676-681, 1992

Lichtor JL, Zacny J, Korttila K, Apfelbaum JL, Lane BS, Rupani G, Thisted RA, Dohrn C: Alcohol after midazolam sedation: does it really matter? Anesth Analg 72:661-666, 1991

Apfelbaum JL: Organization and case selection. Acta Anaesth Scand 35(Suppl):I-33, 1991

Apfelbaum JL: Complications and quality assurance. Acta Anaesth Scand 35(Suppl): I-37, 1991

Korttila K, Östman P, Faure E, Apfelbaum JL, Prunskis J, Ekdawi M, Roizen MF: Randomized comparison of recovery after propofol-nitrous oxide versus thiopentone-isoflurane-nitrous oxide anaesthesia in patients undergoing ambulatory surgery. Acta Anaesthesiol Scand 34:400-403, 1990

Apfelbaum JL: Discussion highlights (part 2). Anesthesiol Rev 17 (Supl 2) 64-66, 1990

Apfelbaum JL: Discussion highlights (part 1). Anesthesiol Rev 17 (Suppl 2):28-31, 1990

Apfelbaum JL: Preoperation evaluation, laboratory screening, and selection of adult surgical outpatients in the 1990s. Anesthesiol Rev 17 (Suppl 2):4-12, 1990 Apfelbaum JL: Ambulatory surgery: A historical perspective. Anesthesiol Rev 17 (Suppl 2):2-3, 1990

Korttila K, Östman PL, Faure E, Apfelbaum JL, Ekdawi M, Roizen MF: Randomized comparison of outcome after propofol-nitrous oxide or enflurane-nitrous oxide anaesthesia in operations of long duration. Can J Anaesth 36:651-657, 1989

Zahl K, Apfelbaum JL: Muscle pain occurs after outpatient laparoscopy despite the substitution of vecuronium for succinylcholine. Anesthesiology 70:408-411, 1989

Marais ML, Maher MW, Wetchler BV, Korttila K, Apfelbaum JL: Reduced demands on recovery room resources with propofol (Diprivan) compared to thiopental-isoflurane. Anesthesiol Rev 16:29-40, 1989

Apfelbaum JL, Schreider BD: Organizational aspects of day-case surgery. Curr Opin Anaesth 1:48-53, 1988

Conahan TJ, Williams GD, Apfelbaum JL, Lecky JH: Airway heating reduces recovery time (cost) in outpatients. Anesthesiology 61:128-130, 1987

Leighton BL, Cheek TG, Gross JB, Apfelbaum JL, Shantz BB, Gutsche BB, Rosenberg H: Succinylcholine pharmacodynamics in peripartum patients. Anesthesiology 64:202-206, 1986

Moss J, Roizen MF, Norbody EJ, Thisted R, Apfelbaum JL, Schreider BD, McDermott DJ: Decreased incidence and mortality of anaphylaxis to chymopapain. Anesth Analg 64:1197-1201, 1985

Apfelbaum JL, Shaw LM, Gross JB, Caldwell CB, Spaulding BC: Modifications of lidocaine protein binding with CO2. Can Anaesth Soc J 32:468-471, 1985

Choi SD, Spaulding BC, Gross JB, Apfelbaum JL: Comparison of the ventilatory effects of etomidate and methohexital. Anesthesiology 62:442-447, 1985

Spaulding BC, Choi SD, Gross JB, Apfelbaum JL, Broderson H: The effect of physostigmine on diazepam-induced ventilatory depression: A double-blind study. Anesthesiology 61:551-554, 1984

Coodley EL, Miller H, Frocco G, Goldzer R, LaBove N, LeSal J, Neimark S, Victor M, Whittington R, Apfelbaum JL: Therapeutic conference: Problem: Fever, nausea, back pain. Emerg Med 16:57-64, 1984

Gross JB, Caldwell CB, Shaw LM, Apfelbaum JL: Effect of lidocaine infusion on the ventilatory response to hypoxia. Anesthesiology 61:662-666, 1984