Jonathan Moss, M.D., Ph.D.

Professor Emeritus of Anesthesia & Critical Care

(773) 702-3091


B.A. - 1965 - 1969
Harvard College - Boston, Massachusetts USA - Biology

M.D. - 1970 - 1974
Duke University Medical Center - Durham, North Carolina USA

Ph D. - 1970 - 1974
Duke University - Durham, North Carolina USA - Physiology and Pharmacology

Internship - 1974 - 1975
Duke University Medical Center - Durham, North Carolina USA - Pediatrics

Residency - 1974 - 1977
Massachusetts General Hospital - Boston, Massachusetts USA - Anesthesia

Fellowship - 1977 - 1978
Harvard Medical School - Boston, Massachusetts USA - Anesthesia

Clinical Interests

Reactions to anesthetic drugs and adjuvants in the perioperative period
The influence of herbal medications in the perioperative period.
Methylinaltrexone, an opiate antagonist that relieves the adverse effects of opiates

Academic Interests

Pharmacology of anesthetic drugs
Autonomic pharmacology; peripheral opiate antagonists
Effects of anesthetic agents on smooth muscle
Effect of sex hormones on cerebral and coronary vessels.

Recent Publications

Mathew B, Lennon FE, Siegler JH, Mirzapoiazova T, Mambetsariev N, Sammani S, Gerhold LM, LaRiviere PJ, Chen C-T, Garcia JGN, Salgia R, Moss J, Singleton PA: Novel role of the mu opioid receptor in lung cancer progression: A laboratory investigation. Anesth Analg 112:558-567, 2011

Singleton PA, Garcia JGN, Moss J: Synergistic effect of methylnaltrexone with 5-fluorouracil (5-FU) and bevacizumab on inhibition of VEGF-induced angiogenesis. Mol Cancer There 7:1669-1679, 2008

Moss J and Rosow CE: Development of peripheral opioid antagonists: New insights into opioid effects. Accompanied by Editorial. Mayo Clinic Proceedings 83:1116-1130, 2008.

Yuan C-S, Wei G, Dey L, Karrison T, Nahlik L, Maleckar S, Kasza K, Ang-Lee M, Moss J: American ginseng reduces warfarin’s effect in healthy subjects: A randomized controlled trial. Ann Int Med 141:23-27, 2004

Ang-Lee, Michael, Moss, J, Yuan, C-S: Herbal medicines and perioperative care. JAMA 286: 208-216, 2001.

Yuan CS, Foss JF, O’Connor M, Osinski J, Karrison T, Moss J Roizen MF: Methylnaltrexone reverses chronic opioid-induced constipation: a randomized, controlled trial. JAMA 283:367-72, 2000

Renz C, Laroche D, Thurn J, Finn H, Lynch J, Thisted R, Moss J: Tryptase levels are not increased during vancomycin-induced anaphylactoid reactions. Anesthesiology, 89:620-5, 1998

Moss J, Rosow CE, Savarese JJ, Philbin DM, and Kniffen KJ: Role of histamine in the hypotensive action of d-tubocurarine in man. Anesthesiology 55:19-25, 1981 (with editorial by M.A. Beaven

Dimsdale JE and Moss J: Plasma catecholamines in stress and exercise. JAMA 243:340-342, 1980

Roizen MF, Moss J, Henry DP, and Kopin IJ: Effect of halothane on plasma catecholamines. Anesthesiology 41:432-439, 1974 (with editorial by S.H. Ngai)