Professor of Anesthesia & Critical Care
Director, Ming Xu lab
5841 S. Maryland Ave.
Chicago, IL 60637
B.S. - 1978 - 1982
Beijing University - Beijing, P.R.China - Chemistry
Ph.D. - 1982 - 1989
University of Texas Southwestern Medical Center - Dallas, Texas USA - Molecular Biology
Fellowship - 1989 - 1995
Massachusetts Institute of Technology - Boston, Massachusetts USA - Molecular Neurobiology
My long-term research interest is to understand mechanisms underlying drug addiction and to find possible treatment. We use behavioral, genetic, anatomical and molecular biological methods. One major research project is to identify mechanisms and neuronal circuits associated with reconsolidation and extinction of cocaine-induced reward memory. Another project is to develop a novel method of using skin stem cells to deliver therapeutic genes to combat the abuse of cocaine, ethanol, nicotine and their co-abuse.
Molecular basis of drug addiction
Yan, Y, Newman, A. H. and Xu, M. (2014). Dopamine D1 and D3 receptors mediate reconsolidation of cocaine memories in mouse models of drug self-administration. Neurosci. In press.
Shao, W., Zhang, S., Tang, M., Zhang, X., Zhou, Z., Yin, Y., Zhou, X., Liu, Y., Huang, Y., Eric Wawrousek, E., Chen, T., Li, L., Xu, M., Zhou, J., Hu, G. and Zhou, J. (2013). Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin. Nature 494: 90-94.
Cao, G., Zhu, J., Zhong, Q., Shi, C., Dang, Y., Han, W., Liu, X., Xu, M. and Chen, T. (2013). Distinct roles of methamphetamine in modulating spatial memory consolidation, retrieval, reconsolidation and the accompanying changes of ERK and CREB activation in hippocampus and prefrontal cortex. Neuropharm. 67: 144-154.
Yan, Y., Kong, H., Wu, E.J., Newman, A. H. and Xu, M. (2013) Dopamine D3 receptors regulate reconsolidation of cocaine memory. Neurosci. 241: 32-40.
Zhu, J., Chen, Y., Cao, G., Zhao, N., Xu, M. and Chen, T. (2012). Dopamine D3 receptors regulate methamphetamine-induced behavioral sensitization but not ultra-structural plasticity in the shell of nucleus accumbens. J. Neurosci. Res. 90: 895-904.
Caine, S.B., Thomsen, M., Barrett, A.C., Collins, G.T., Grundt, P., Newman, A.H., Butler, P. and Xu, M. (2012). The dopamine D3 receptor is not necessary for cocaine self-administration: studies in D3 knockout mice. Exp. Clinical Psychopharm. 20: 352-363.
Kong, H. and Xu, M. (2011). Exploring mechanisms underlying extinction of cue-elicited cocaine seeking. Current Neuropharm. 9: 8-11.
Kong, H., Kuang, W., Li, S. and Xu, M. (2011). Activation of dopamine D3 receptors inhibits reward-related learning induced by cocaine. Neurosci. 176: 152-161.
Xing, B., Kong, H., Meng, X., Wei, S., Xu, M. and Li, S. (2010). Dopamine D1 but not D3 receptor is critical for spatial memory and related signaling in the hippocampus. Neurosci. 169: 1511-1519.
Ren, Z., Sun, W., Jiao, H., Zhang, D., Kong, H., Wang, X. and Xu, M. (2010). Dopamine D1 and NMDA receptors and ERK mediate neuronal morphological changes induced by repeated cocaine administration. Neurosci. 168: 48-60.
Chen, L.P. and Xu, M. (2010). Dopamine D1 and D3 receptors are differentially involved in cue-elicited cocaine seeking. J. Neurochem. 114: 530-541.
Fan, X., Xu, M. and Hess, E.J. (2010). D2 dopamine receptor subtype-mediated hyperactivity and amphetamine responses in a model of ADHD. Neurobio. Dis. 37: 228-236.
Liu, X., Mao, L., Zhang, G., Papasian, C.J., Fibuch, E.E., Lan, H., Zhou, H., Xu, M.* and Wang, J.Q.* (2009). Activity- dependent modulation of limbic dopamine D3 receptors by CaMKII. Neuron 61: 425-438. *Co-correspondence. Work described in the Liu et al. paper received a special commentary. See Hell, J.W. (2009). Hooked on the D3 Receptor: CaMKII's new addiction. Neuron 61: 335-336.
Campioni, M., Xu, M. and McGehee, D.S. (2009). Stress-induced changes in nucleus accumbens glutamate synaptic plasticity. J. Neurophys. 101: 3192-3198.
Zhou, F-W., Jin, Y., Matta, S., Xu, M. and Zhou, F-M. (2009). An ultra-short dopamine pathway regulates basal ganglia output. J. Neurosci. 29: 10424-10435.
Hu, X.T., Nasif, F.J., Zhang, J. and Xu, M. (2008). Fos regulates neuronal activity in the nucleus accumbens. Neurosci. Letters 448: 157-160.
Caine, S.B., Thomsen, M., Gabriel, K.I., Berkowitz, J.S., Gold, L.H., Koob, G.F., Tonegawa, S., Zhang, J. and Xu, M. (2007). Decreased cocaine self-administration in dopamine D-1 receptor knockout mice. J. Neurosci. 27: 13140-13150.
Jiao, H., Zhang, L., Gao, F., Lou, D., Zhang, J. and Xu, M. (2007). Dopamine D1 and D3 receptors oppositely regulate NMDA- and cocaine-induced MAPK signaling via NMDA receptor phosphorylation. J. Neurochem. 103: 840-848.
Zhang, J., Zhang, L., Jiao, H., Zhang, Q., Zhang, D., Lou, D., Katz, J., and Xu, M. (2006). c-fos facilitates acquisition and extinction of cocaine-induced persistent change. J. Neurosci. 26: 13287-13296.