Steven Roth, M.D.

Professor Emeritus of Anesthesia & Critical Care

Training

B.A. - 1974 - 1978
New York University - New York, NY USA - Chemistry

M.D. - 1978 - 1982
Albert Einstein College of Medicine - New York, NY USA

Internship - 1982 - 1983
Downstate Med Center - Brooklyn, NY USA - Medicine

Residency - 1985 - 1986
NYU Med Center - New York, NY USA - Anesthesiology

Fellowship - 1985 - 1986
Cleveland Clinic Foundation - Cleveland, OH USA - Neuroanesthesia

Clinical Interests

Anesthesia for neurosurgery
Anesthesia for spine surgery

Academic Interests

Molecular mechanisms of endogenous neuroprotection. PI NIH grant EY10343
Stem cell mediated neuroprotection
Basic and clinical studies of perioperative visual loss
Outcome studies in large clinical databases

Recent Publications

Li B, Roth S: Retinal ischemic preconditioning in the rat: requirement for adenosine and repetitive induction. Investigative Ophthalmology and Visual Science 40:1200-1216, 1999.

Li B, Jennings NM, Rosenbaum PS, Maxwell KM, Roth S: Differing roles of adenosine receptor subtypes in retinal ischemia-reperfusion injury in the rat. Experimental Eye Research 68:9-17, 1999.

Ghiardi GJ, Gidday JM, Roth S: The purine nucleoside adenosine in retinal ischemia-reperfusion injury. Vision Research 39:2519-2535, 1999.

Lin J, Roth S: Ischemic preconditioning attenuates hypoperfusion after retinal ischemia in rats. Investigative Ophthalmology and Visual Science 40:2925-2931,1999.

Foroohar M, Macdonald RL, Roth S, Stoodley M, Weir BK: Intraoperative variables and early outcome after aneurysm surgery. Surgical Neurology 54:304-314, 2000

Li B, Yang C, Rosenbaum DM, Roth S: Signal transduction mechanisms involved in ischemic preconditioning in the rat retina in vivo. Experimental Eye Research 70:755-765, 2000.

Rosenbaum DM, Rosenbaum PS, Singh M, Gupta G, Gupta H, Li B, Roth S: Functional and morphological comparison of two methods to produce transient retinal ischemia in the rat. Journal of Neuro-ophthalmology 21: 62-68, 2001.

Singh M, Savitz SI, Hoque R, Gupta G, Rosenbaum PS, Roth S, Rosenbaum DM: Cell-specific caspase expression by different neuronal phenotypes in transient retinal ischemia. Journal of Neurochemistry 77: 466-475, 2001.

Roth S, Barach P: Post-operative visual loss-no answers-yet (Editorial View). Anesthesiology 95: 575-577, 2001.

Zhang C, Rosenbaum DM, Shaikh AR, Li Q, Rosenbaum PS, Pelham DJ, Roth S: Ischemic preconditioning attenuates apoptotic cell death in the rat retina. Investigative Ophthalmology and Visual Science 43: 3059-3066, 2002.

Junk AK, Mammis A, Savitz SI, Singh M, Roth S, Malhotra S, Rosenbaum PS, Cerami A, Brines M, Rosenbaum DM. Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury. Proceedings of the National Academy of Sciences of the United States of America. 99:10659-10664, 2002

Roth S: Mechanisms of ischemic preconditioning in the retina. Brain Research Bulletin 62:461-466, 2003.

Li Y, Roth S, Laser M, Ma JX, Crosson CE. Retinal preconditioning and the induction of heat-shock protein 27. Investigative Ophthalmology and Visual Science 44:1299-304, 2003.

Roth S, Shaikh AR, Li Q, Hennelly MM, Bindokas V, Graham CE: Mitogen-activated protein kinases and retinal ischemia. Investigative Ophthalmology and Visual Science 44:5383-5395, 2003.

Ho V T-G, Newman NJ, Song S, Ksiasek S, Roth S: Ischemic optic neuropathy after spine surgery. J Neurosurg Anesthesiol 17:38-44, 2005. Steven Roth, M.D. 33

Tung A, Roth S, O’Connor MF, Liu W, Ellis JE: Fulminant hepatic failure after radical prostatectomy in the hyperlordotic position. Anesth Analg 103: 986-988, 2006.

Roth S, Dreixler JC, Shaikh AR, Lee KH, Bindokas V: Mitochondrial potassium ATP channels and retinal ischemic preconditioning. Invest Ophthalmol Vis Sci 47:2114-2124, 2006.

Arens JF, Connis RT, Domino KB, Lee LA, Miller NR, Mirza SK, Newman NJ, Nickinovich DG, Roth S, Savino PJ, Warner MA (chair), Weinstein P. Practice Advisory for Perioperative Visual Loss Associated with Spine Surgery. A Report by the American Society of Anesthesiologists Task Force on Perioperative Blindness. Anesthesiology 104:1319-1328, 2006.

Lee LA, Roth S, Posner KL, Cheney FW, Caplan RA, Newman NJ, Domino KB: The American Society of Anesthesiologists postoperative visual loss registry: Analysis of 93 spine cases with postoperative visual loss. Anesthesiology 105:652-659, 2006.

Roth S, Tung A, Ksiasek S: Visual loss due to eye protectors in a prone-positioned patient: An old complication with a new mechanism. Anesthesia and Analgesia 104: 1185-1187, 2007.

Dreixler JC, Shaikh AR, Shenoy SS, Shen Y, Roth S: Protein kinase C subtypes and retinal ischemic preconditioning. Experimental Eye Research 87: 300-311, 2008.

Dauber MH, Roth S: Hazards of the Jackson spinal table. Anesthesia and Analgesia 108:904-5, 2009.

Dreixler JC, Hemmert JW, Shenoy SS, Shen Y, Lee HT, Shaikh AR, Rosenbaum DM, Roth S: Akt/Protein kinase B subtypes and retinal ischemic preconditioning. Experimental Eye Research 88:512-521, 2009

Shen Y, Drum M, Roth S: Prevalence of perioperative visual loss in the United States: A study of general, cardiac, and spine surgery. Anesthesia and Analgesia, 109:1534-1545, 2009

Shen Y, Silverstein J, Roth S: In hospital complications and mortality after elective spinal fusion surgery in the United States: A study of the Nationwide Inpatient Sample from 2001 to 2005. Journal of Neurosurgical Anesthesiology 21: 21-30, 2009. Steven Roth, M.D. 34

Awad H, Ohr M, Roth S, Roth A, Santilli S, Yan W, Fernandez S, Patel, P. The effects of steep Trendelenburg positioning on intraocular pressure during robotic radical prostatectomy. Anesthesia and Analgesia 109:473-8, 2009.

Dreixler JC, Hagevik S, Hemmert JW, Shaikh AR, Rosenbaum DM, Roth S: Involvement of erythropoietin in retinal ischemic preconditioning. Anesthesiology 110:774-780, 2009.

Dreixler JC, Shaikh AR, Savoie B, Du E, Roth S: p38 alpha in retinal ischemic preconditioning. Experimental Eye Research 88:512-21, 2009

Hughey A, Lesniak M, Ansari S, Roth S: What will anesthesiologists be anesthetizing? Trends in neurosurgical and neuromuscular procedures in the United States from 1993 to 2007: A study of the Nationwide Inpatient Sample Anesthesia and Analgesia 110:1686-97, 2010.

Savitz SI, Degterov A, David J, Rosenbaum PS, Roth S, Grotta JC, Cuny GD, Yuan J, Rosenbaum DM: Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model. Journal of Neuroscience Methods 88: 1569-76, 2010

Roth S: Perioperative visual loss: What do we know, what can we do? British Journal of Anaesthesia 103 (supple): i31-i40, 2010.

Dreixler JC, Shaikh AR, Alexander M, Savoie. B, Roth S: Postischemic conditioning in the rat retina is dependent upon ischemia duration and is not additive with ischemic preconditioning. Experimental Eye Research 91: 844-852, 2010.

Dreixler JC, Bratton A, Du E, Shaikh AR, Marcet M, Roth S: Mitogen activated protein kinase phosphatase-1 (MKP-1) in retinal ischemic preconditioning. Experimental Eye Research in press, doi:10.1016/j.exer.2010.10.011

David J, Melamud A, Kesner L, Roth S, Rosenbaum PS, Barone FC, Popp S, Hassen GW, Stracher A, Rosenbaum DM. A novel calpain inhibitor for the treatment of transient retinal ischemia in the rat. Neuroreport 22: 633-636, 2011.

Marcet MM, Lemke BN, Greenwald MJ, Fountain TR, Roth S, Dubovy SR: New insights into micro anatomy of the eyelid. British Journal of Ophthalmology, in press.

Dreixler JC, Sampat A, Shaikh AR, Marcet MM, Roth S: Akt and MAPK p38 in retinal ischemic postconditioning. Journal of Molecular Neuroscience (in press)

Dreixler JC, Poston JN, Shaikh AR, Alexander MJ, Tupper KY, Marcet MM, Bernaudin M, Roth S: Delayed post-conditioning significantly improves outcome after retinal ischemia in rats. Experimental Eye Research 92: 521-527, 2011.

Arens JF, Connis RT, Domino KB, Lee LA, Miller NR, Mirza SK, Newman NJ, Nickinovich DG, Roth S (chair), Savino PJ, Warner MA, Weinstein P. Practice Advisory for Perioperative Visual Loss Associated with Spine Surgery: An Updated Report by the American Society of Anesthesiologists Task Force on Perioperative Blindness. Anesthesiology 116:274-285, 2012

Marcet MM, Meyer DR, Greenwald MJ, Roth S, Selva D. Proximal tarsal attachments of the levator aponeurosis: implications for blepharoptosis repair. Ophthalmology. 120:1924-9, 2013.

Dreixler JC, Poston JN, Balyasnikov I, Shaikh AR, Tupper Y, Marcet MM, Lesniak MS, Roth S. Delayed administration of conditioned media from bone marrow mesenchymal stem cells rescue the retina after retinal ischemia. In revision, Investigative Ophthalmology and Visual Science. 

Sampat A, Glick D, Roth S. Eye complications in robotic-assisted laparoscopic prostatectomy. A 10 year review of a national database. In revision, Anesthesiology. 

Roth S, Dreixler JC, Conway S, Boddapatti V, Shaikh AR, Tupper KY, Alexander JM, Savoie B, Marcet MM, Newman NJ. A rodent model of perioperative ischemic optic neuropathy. Submitted to Anesthesiology.