Dr. Groman is an Assistant Professor in the Department of Anesthesia and Critical Care at the University of Chicago. Her research program is investigating the neurobiological mechanisms of decision-making in normal and pathological states, with a particular interest in addiction. Her lab integrates behavioral paradigms with computational analyses, neuroimaging approaches, systems-level manipulations, and molecular analyses in rodents to generate mechanistic links between genes, signaling mechanisms, and behavior that can help us understand the pathology of addiction.
Disruptions in Reward-Guided Decision-Making Functions Are Predictive of Greater Oral Oxycodone Self-Administration in Male and Female Rats.
Disruptions in Reward-Guided Decision-Making Functions Are Predictive of Greater Oral Oxycodone Self-Administration in Male and Female Rats. Biol Psychiatry Glob Open Sci. 2025 May; 5(3):100450.
PMID: 40083740
Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia.
Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia. Cell Rep. 2024 06 25; 43(6):114355.
PMID: 38870010
Sex differences in oxycodone-taking behaviors are linked to disruptions in reward-guided, decision-making functions.
Sex differences in oxycodone-taking behaviors are linked to disruptions in reward-guided, decision-making functions. bioRxiv. 2024 Apr 11.
PMID: 38645212
Reward-Mediated, Model-Free Reinforcement-Learning Mechanisms in Pavlovian and Instrumental Tasks Are Related.
Reward-Mediated, Model-Free Reinforcement-Learning Mechanisms in Pavlovian and Instrumental Tasks Are Related. J Neurosci. 2023 01 18; 43(3):458-471.
PMID: 36216504
Examining sex differences in responses to footshock stress and the role of the metabotropic glutamate receptor 5: an [18F]FPEB and positron emission tomography study in rats.
Examining sex differences in responses to footshock stress and the role of the metabotropic glutamate receptor 5: an [18F]FPEB and positron emission tomography study in rats. Neuropsychopharmacology. 2023 02; 48(3):489-497.
PMID: 36100654
Adolescent reinforcement-learning trajectories predict cocaine-taking behaviors in adult male and female rats.
Adolescent reinforcement-learning trajectories predict cocaine-taking behaviors in adult male and female rats. Psychopharmacology (Berl). 2022 Sep; 239(9):2885-2901.
PMID: 35705734
Imaging the fetal nonhuman primate brain with SV2A positron emission tomography (PET).
Imaging the fetal nonhuman primate brain with SV2A positron emission tomography (PET). Eur J Nucl Med Mol Imaging. 2022 09; 49(11):3679-3691.
PMID: 35633376
MicroPET evidence for a hypersensitive neuroinflammatory profile of gp120 mouse model of HIV.
MicroPET evidence for a hypersensitive neuroinflammatory profile of gp120 mouse model of HIV. Psychiatry Res Neuroimaging. 2022 04; 321:111445.
PMID: 35101828
Reinforcement learning detuned in addiction: integrative and translational approaches.
Reinforcement learning detuned in addiction: integrative and translational approaches. Trends Neurosci. 2022 02; 45(2):96-105.
PMID: 34920884
Paranoia and belief updating during the COVID-19 crisis.
Paranoia and belief updating during the COVID-19 crisis. Nat Hum Behav. 2021 09; 5(9):1190-1202.
PMID: 34316049