People

Peter Nagele, MD

  • Chair of Anesthesia and Critical Care
    Professor of Anesthesia and Critical Care
    Professor of Psychiatry and Behavioral Neuroscience
    Committee on Clinical Pharmacology and Pharmacogenomics
  • Research and Scholarly Interests: cardiac biomarker, Depression, Myocardial Infarction, Nitrous Oxide, Outcomes Research, Suicide, Trials, Randomized Clinical, Troponin
  • Websites: Research Network Profile
  • Contact: nagelep@uchicago.edu

Dr. Nagele is an internationally recognized trauma anesthesiologist, researcher and educator. An authority on perioperative outcomes research, he focuses on to better predict, diagnose, prevent, and treat major cardiac events in surgical patients. He discovered that novel heart biomarkers may predict heart attacks in patients undergoing non-cardiac surgery.

He has also conducted ground-breaking work suggesting that a brief inhalation of nitrous oxide, commonly known as laughing gas, improves severe symptoms of depression and suicidal thoughts.

Evaluation of Appropriate Use of Preoperative Echocardiography before Major Abdominal Surgery: A Retrospective Cohort Study.
Tank A, Hughey R, Ward RP, Nagele P, Rubin DS. Evaluation of Appropriate Use of Preoperative Echocardiography before Major Abdominal Surgery: A Retrospective Cohort Study. Anesthesiology. 2021 Nov 01; 135(5):854-863.
PMID: 34543408

NT-proBNP in young healthy adults undergoing non-cardiac surgery.
Duma A, Maleczek M, Wagner C, Haslacher H, Szekeres T, Jaffe AS, Nagele P. NT-proBNP in young healthy adults undergoing non-cardiac surgery. Clin Biochem. 2021 Oct; 96:38-42.
PMID: 34265286

A phase 2 trial of inhaled nitrous oxide for treatment-resistant major depression.
Nagele P, Palanca BJ, Gott B, Brown F, Barnes L, Nguyen T, Xiong W, Salloum NC, Espejo GD, Lessov-Schlaggar CN, Jain N, Cheng WWL, Komen H, Yee B, Bolzenius JD, Janski A, Gibbons R, Zorumski CF, Conway CR. A phase 2 trial of inhaled nitrous oxide for treatment-resistant major depression. Sci Transl Med. 2021 06 09; 13(597).
PMID: 34108247

Expert consensus on peri-operative myocardial injury screening in noncardiac surgery: A literature review.
Puelacher C, Bollen Pinto B, Mills NL, Duceppe E, Popova E, Duma A, Nagele P, Omland T, Hammerer-Lercher A, Lurati Buse G. Expert consensus on peri-operative myocardial injury screening in noncardiac surgery: A literature review. Eur J Anaesthesiol. 2021 Jun 01; 38(6):600-608.
PMID: 33653981

U.S. trends in elective and emergent major abdominal surgical procedures from 2002 to 2014 in older adults.
Rubin DS, Huisingh-Scheetz M, Ferguson MK, Nagele P, Peden CJ, Lauderdale DS. U.S. trends in elective and emergent major abdominal surgical procedures from 2002 to 2014 in older adults. J Am Geriatr Soc. 2021 08; 69(8):2220-2230.
PMID: 33969889

Frequency and Outcomes of Preoperative Stress Testing in Total Hip and Knee Arthroplasty from 2004 to 2017.
Rubin DS, Hughey R, Gerlach RM, Ham SA, Ward RP, Nagele P. Frequency and Outcomes of Preoperative Stress Testing in Total Hip and Knee Arthroplasty from 2004 to 2017. JAMA Cardiol. 2021 Jan 01; 6(1):13-20.
PMID: 32997100

Systematic review and consensus definitions for the Standardized Endpoints in Perioperative Medicine (StEP) initiative: cardiovascular outcomes.
Beattie WS, Lalu M, Bocock M, Feng S, Wijeysundera DN, Nagele P, Fleisher LA, Kurz A, Biccard B, Leslie K, Howell S, Landoni G, Grocott H, Lamy A, Richards T, Myles P. Systematic review and consensus definitions for the Standardized Endpoints in Perioperative Medicine (StEP) initiative: cardiovascular outcomes. Br J Anaesth. 2021 01; 126(1):56-66.
PMID: 33092804

Morbidity and Mortality After Acute Myocardial Infarction After Elective Major Noncardiac Surgery.
Ranjeva SL, Tung A, Nagele P, Rubin DS. Morbidity and Mortality After Acute Myocardial Infarction After Elective Major Noncardiac Surgery. J Cardiothorac Vasc Anesth. 2021 Mar; 35(3):834-842.
PMID: 33153868

Frequency and Outcomes of Preoperative Stress Testing in Total Hip and Knee Arthroplasty from 2004 to 2017.
Rubin DS, Hughey R, Gerlach RM, Ham SA, Ward RP, Nagele P. Frequency and Outcomes of Preoperative Stress Testing in Total Hip and Knee Arthroplasty from 2004 to 2017. JAMA Cardiol. 2020 Sep 30.
PMID: 32997100

Generalisability of randomised trials evaluating perioperative ß-blocker therapy in noncardiac surgery.
Titz M, Schwameis M, Kienbacher C, Buchtele N, Roth D, Duma A, Nagele P, Schörgenhofer C, Herkner H. Generalisability of randomised trials evaluating perioperative ß-blocker therapy in noncardiac surgery. Br J Anaesth. 2020 12; 125(6):926-934.
PMID: 32888632

View All Publications

Fellow
American Heart Association
2018

NARSAD Independent Investigator Grant
Brain & Behavior Research Foundation
2016

Ziskind-Somerfeld Research Award
Society for Biological Psychiatry
2016

Mentor of the Year
Clinical Research Training Center, Washington University School of Medicine
2014

Presidential Scholar Award
American Society of Anesthesiologists
2012

Billroth Prize
Vienna Medical Society (Austria)
2011

Elmer-Zsigmond Award
International Society for Anesthetic Pharmacology
2007

Otto-Kraupp-Prize
2006

Research Starter Grant
European Society of Anaesthesiology
2005

Resident’s Research Essay Contest Award
American Society for Anesthesiology
2005