People

Peter Nagele, MD

  • Chair of Anesthesia and Critical Care
    Professor of Anesthesia and Critical Care
    Committee on Clinical Pharmacology and Pharmacogenomics
  • Research and Scholarly Interests: cardiac biomarker, Depression, Myocardial Infarction, Nitrous Oxide, Outcomes Research, Suicide, Trials, Randomized Clinical, Troponin
  • Websites: Research Network Profile
  • Contact: nagelep@uchicago.edu

Dr. Nagele is an internationally recognized trauma anesthesiologist, researcher and educator. An authority on perioperative outcomes research, he focuses on to better predict, diagnose, prevent, and treat major cardiac events in surgical patients. He discovered that novel heart biomarkers may predict heart attacks in patients undergoing non-cardiac surgery.

He has also conducted ground-breaking work suggesting that a brief inhalation of nitrous oxide, commonly known as laughing gas, improves severe symptoms of depression and suicidal thoughts.

Frequency and Outcomes of Preoperative Stress Testing in Total Hip and Knee Arthroplasty from 2004 to 2017.
Rubin DS, Hughey R, Gerlach RM, Ham SA, Ward RP, Nagele P. Frequency and Outcomes of Preoperative Stress Testing in Total Hip and Knee Arthroplasty from 2004 to 2017. JAMA Cardiol. 2020 Sep 30.
PMID: 32997100

Generalisability of randomised trials evaluating perioperative ß-blocker therapy in noncardiac surgery.
Titz M, Schwameis M, Kienbacher C, Buchtele N, Roth D, Duma A, Nagele P, Schörgenhofer C, Herkner H. Generalisability of randomised trials evaluating perioperative ß-blocker therapy in noncardiac surgery. Br J Anaesth. 2020 Sep 01.
PMID: 32888632

Prolonged Remission of Major Depressive Disorder After Single Nitrous Oxide Inhalation Treatment.
Nagele P, Brown F, Bass V, Yohanna D. Prolonged Remission of Major Depressive Disorder After Single Nitrous Oxide Inhalation Treatment. Front Psychiatry. 2020; 11:692.
PMID: 32765325

Perioperative Myocardial Injury and Infarction: Top-20 List of What We Know and What We Don't.
Nagele P. Perioperative Myocardial Injury and Infarction: Top-20 List of What We Know and What We Don't. Anesth Analg. 2020 07; 131(1):170-172.
PMID: 32541590

Does Nitrous Oxide Help Veterans With Posttraumatic Stress Disorder? A Case Series.
Varias A, van Roessel P, Parsiani M, Filippou-Frye M, Neylan TC, Nagele P, Yesavage J, Clark JD, Rodriguez CI. Does Nitrous Oxide Help Veterans With Posttraumatic Stress Disorder? A Case Series. J Clin Psychiatry. 2020 06 30; 81(4).
PMID: 32609959

Association Between Myocardial Injury and Cardiovascular Outcomes of Orthopaedic Surgery: A Vascular Events in Noncardiac Surgery Patients Cohort Evaluation (VISION) Substudy.
Thomas S, Borges F, Bhandari M, De Beer J, Urrútia Cuchí G, Adili A, Winemaker M, Avram V, Chan MTV, Lamas C, Cruz P, Aguilera X, Garutti I, Alonso-Coello P, Villar JC, Jacka M, Wang CY, Berwanger O, Chow C, Srinathan S, Pettit S, Heels-Ansdell D, Rubery P, Devereaux PJ, Thomas S, Walsh M, Tiboni M, Guyatt G, Heels-Ansdell D, Thorlund K, Thabane L, Bhandari M, Bosch J, Chan MTV, Shatin NT, Alonso-Coello P, Berwanger O, Carlos Villar J, Wang CY, Garutti RI, Jacka MJ, Sigamani A, Srinathan S, Biccard BM, Rodseth RN, Chow CK, Abraham V, Pettit S, McQueen MJ, VanHelder T, Szczeklik W, Buse GL, Botto F, Yusuf S, Sessler DI, Kurz A, Garg AX, Mrkobrada M, Pearse RM, Polanczyk CA, Malaga G, Nagele P, Le Manach Y, Leuwer M, Devereaux PJ. Association Between Myocardial Injury and Cardiovascular Outcomes of Orthopaedic Surgery: A Vascular Events in Noncardiac Surgery Patients Cohort Evaluation (VISION) Substudy. J Bone Joint Surg Am. 2020 May 20; 102(10):880-888.
PMID: 32118652

A Simplified Proposal to Redefine Acute Myocardial Infarction Versus Acute Myocardial Injury.
Nagele P. A Simplified Proposal to Redefine Acute Myocardial Infarction Versus Acute Myocardial Injury. Circulation. 2020 May 05; 141(18):1431-1433.
PMID: 32364777

Ketamine and nitrous oxide: The evolution of NMDA receptor antagonists as antidepressant agents.
Kalmoe MC, Janski AM, Zorumski CF, Nagele P, Palanca BJ, Conway CR. Ketamine and nitrous oxide: The evolution of NMDA receptor antagonists as antidepressant agents. J Neurol Sci. 2020 05 15; 412:116778.
PMID: 32240970

Epicardial Adipose Tissue: An Independent Predictor of Post-Operative Adverse Cardiovascular Events (CTA VISION Substudy).
Massalha S, Walpot J, Dey D, Guler EC, Clarkin O, Godkin L, Ratnayake I, Jayasinghe P, Hossain A, Crean A, Chan M, Butler C, Tandon V, Nagele P, Woodard PK, Mrkobrada M, Szczeklik W, Abdul Aziz YF, Biccard B, Devereaux PJ, Sheth T, Chow BJW. Epicardial Adipose Tissue: An Independent Predictor of Post-Operative Adverse Cardiovascular Events (CTA VISION Substudy). JACC Cardiovasc Imaging. 2020 Mar; 13(3):882-884.
PMID: 31734207

Elevated cardiac troponin before surgery: perhaps not so benign.
Nagele P. Elevated cardiac troponin before surgery: perhaps not so benign. Br J Anaesth. 2020 01; 124(1):6-7.
PMID: 31685217

View All Publications

Fellow
American Heart Association
2018

NARSAD Independent Investigator Grant
Brain & Behavior Research Foundation
2016

Ziskind-Somerfeld Research Award
Society for Biological Psychiatry
2016

Mentor of the Year
Clinical Research Training Center, Washington University School of Medicine
2014

Presidential Scholar Award
American Society of Anesthesiologists
2012

Billroth Prize
Vienna Medical Society (Austria)
2011

Elmer-Zsigmond Award
International Society for Anesthetic Pharmacology
2007

Otto-Kraupp-Prize
2006

Research Starter Grant
European Society of Anaesthesiology
2005

Resident’s Research Essay Contest Award
American Society for Anesthesiology
2005