People

Peter Nagele, MD

  • Chair of Anesthesia and Critical Care
    Professor of Anesthesia and Critical Care
  • Research and Scholarly Interests: cardiac biomarker, Depression, Myocardial Infarction, Nitrous Oxide, Outcomes Research, Suicide, Trials, Randomized Clinical, Troponin
  • Websites: Research Network Profile
  • Contact: nagelep@uchicago.edu

Dr. Nagele is an internationally recognized trauma anesthesiologist, researcher and educator. An authority on perioperative outcomes research, he focuses on to better predict, diagnose, prevent, and treat major cardiac events in surgical patients. He discovered that novel heart biomarkers may predict heart attacks in patients undergoing non-cardiac surgery.

He has also conducted ground-breaking work suggesting that a brief inhalation of nitrous oxide, commonly known as laughing gas, improves severe symptoms of depression and suicidal thoughts.

Accuracy of Physical Function Questions to Predict Moderate-Vigorous Physical Activity as Measured by Hip Accelerometry.
Rubin DS, Huisingh-Scheetz M, Hung A, Ward RP, Nagele P, Arena R, Hedeker D. Accuracy of Physical Function Questions to Predict Moderate-Vigorous Physical Activity as Measured by Hip Accelerometry. Anesthesiology. 2019 11; 131(5):992-1003.
PMID: 31490293

Elevated cardiac troponin before surgery: perhaps not so benign.
Nagele P. Elevated cardiac troponin before surgery: perhaps not so benign. Br J Anaesth. 2019 Nov 01.
PMID: 31685217

Cardiac Events after Electroconvulsive Therapy: Reply.
Duma A, Nagele P. Cardiac Events after Electroconvulsive Therapy: Reply. Anesthesiology. 2019 Oct; 131(4):942.
PMID: 31436543

Response to comments on 'The European Society of Anaesthesiology Task Force review on the place of nitrous oxide in current clinical practice' (Br J Anaesth 2019; 122:587-604).
Buhre W, Disma N, Hendrickx J, De Hert S, Hollmann MW, Huhn R, Jakobsson J, Nagele P, Peyton P, Vutskits L. Response to comments on 'The European Society of Anaesthesiology Task Force review on the place of nitrous oxide in current clinical practice' (Br J Anaesth 2019; 122:587-604). Br J Anaesth. 2019 10; 123(4):e482-e483.
PMID: 31371021

High-Sensitivity Cardiac Troponin After Cardiac Stress Test: A Systematic Review and Meta-Analysis.
Samaha E, Avila A, Helwani MA, Ben Abdallah A, Jaffe AS, Scott MG, Nagele P. High-Sensitivity Cardiac Troponin After Cardiac Stress Test: A Systematic Review and Meta-Analysis. J Am Heart Assoc. 2019 Mar 19; 8(6):e008626.
PMID: 30871395

European Society of Anaesthesiology Task Force on Nitrous Oxide: a narrative review of its role in clinical practice.
Buhre W, Disma N, Hendrickx J, DeHert S, Hollmann MW, Huhn R, Jakobsson J, Nagele P, Peyton P, Vutskits L. European Society of Anaesthesiology Task Force on Nitrous Oxide: a narrative review of its role in clinical practice. Br J Anaesth. 2019 May; 122(5):587-604.
PMID: 30916011

Major Adverse Cardiac Events and Mortality Associated with Electroconvulsive Therapy: A Systematic Review and Meta-analysis.
Duma A, Maleczek M, Panjikaran B, Herkner H, Karrison T, Nagele P. Major Adverse Cardiac Events and Mortality Associated with Electroconvulsive Therapy: A Systematic Review and Meta-analysis. Anesthesiology. 2019 01; 130(1):83-91.
PMID: 30557212

High-sensitivity cardiac troponin T increases after stress echocardiography.
Samaha E, Brown J, Brown F, Martinez SC, Scott M, Jaffe AS, Davila-Roman VG, Nagele P. High-sensitivity cardiac troponin T increases after stress echocardiography. Clin Biochem. 2019 Jan; 63:18-23.
PMID: 30502318

Effect of Nitrous Oxide as a Treatment for Subjective, Idiopathic, Nonpulsatile Bothersome Tinnitus: A Randomized Clinical Trial.
Hong HY, Karadaghy O, Kallogjeri D, Brown FT, Yee B, Piccirillo JF, Nagele P. Effect of Nitrous Oxide as a Treatment for Subjective, Idiopathic, Nonpulsatile Bothersome Tinnitus: A Randomized Clinical Trial. JAMA Otolaryngol Head Neck Surg. 2018 09 01; 144(9):781-787.
PMID: 30073285

Etiology of Acute Coronary Syndrome after Noncardiac Surgery.
Helwani MA, Amin A, Lavigne P, Rao S, Oesterreich S, Samaha E, Brown JC, Nagele P. Etiology of Acute Coronary Syndrome after Noncardiac Surgery. Anesthesiology. 2018 06; 128(6):1084-1091.
PMID: 29481375

View All Publications

Fellow
American Heart Association
2018

NARSAD Independent Investigator Grant
Brain & Behavior Research Foundation
2016

Ziskind-Somerfeld Research Award
Society for Biological Psychiatry
2016

Mentor of the Year
Clinical Research Training Center, Washington University School of Medicine
2014

Presidential Scholar Award
American Society of Anesthesiologists
2012

Billroth Prize
Vienna Medical Society (Austria)
2011

Elmer-Zsigmond Award
International Society for Anesthetic Pharmacology
2007

Otto-Kraupp-Prize
2006

Research Starter Grant
European Society of Anaesthesiology
2005

Resident’s Research Essay Contest Award
American Society for Anesthesiology
2005