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Zheng Xie, MD PhD

Caffeine reverses the unconsciousness produced by light anesthesia in the continued presence of isoflurane in rats.
Fox AP, Wagner KR, Towle VL, Xie KG, Xie Z. Caffeine reverses the unconsciousness produced by light anesthesia in the continued presence of isoflurane in rats. PLoS One. 2020; 15(11):e0241818.
PMID: 33152041

A pilot study showing that repeated exposure to stress produces alterations in subsequent responses to anesthetics in rats.
Wang L, Holland L, Fong R, Khokhar S, Fox AP, Xie Z. A pilot study showing that repeated exposure to stress produces alterations in subsequent responses to anesthetics in rats. PLoS One. 2019; 14(3):e0214093.
PMID: 30908509

Caffeine Accelerates Emergence from Isoflurane Anesthesia in Humans: A Randomized, Double-blind, Crossover Study.
Fong R, Wang L, Zacny JP, Khokhar S, Apfelbaum JL, Fox AP, Xie Z. Caffeine Accelerates Emergence from Isoflurane Anesthesia in Humans: A Randomized, Double-blind, Crossover Study. Anesthesiology. 2018 11; 129(5):912-920.
PMID: 30044241

Caffeine accelerates recovery from general anesthesia via multiple pathways.
Fong R, Khokhar S, Chowdhury AN, Xie KG, Wong JH, Fox AP, Xie Z. Caffeine accelerates recovery from general anesthesia via multiple pathways. J Neurophysiol. 2017 09 01; 118(3):1591-1597.
PMID: 28659466

Caffeine accelerates recovery from general anesthesia.
Wang Q, Fong R, Mason P, Fox AP, Xie Z. Caffeine accelerates recovery from general anesthesia. J Neurophysiol. 2014 Mar; 111(6):1331-40.
PMID: 24375022

Interaction of anesthetics with neurotransmitter release machinery proteins.
Xie Z, McMillan K, Pike CM, Cahill AL, Herring BE, Wang Q, Fox AP. Interaction of anesthetics with neurotransmitter release machinery proteins. J Neurophysiol. 2013 Feb; 109(3):758-67.
PMID: 23136341

Three-in-one nerve block with different concentrations of bupivacaine in total knee arthroplasty: randomized, placebo-controlled, double-blind trial.
Xie Z, Hussain W, Cutter TW, Apfelbaum JL, Drum ML, Manning DW. Three-in-one nerve block with different concentrations of bupivacaine in total knee arthroplasty: randomized, placebo-controlled, double-blind trial. J Arthroplasty. 2012 May; 27(5):673-8.e1.
PMID: 21945081

Etomidate and propofol inhibit the neurotransmitter release machinery at different sites.
Herring BE, McMillan K, Pike CM, Marks J, Fox AP, Xie Z. Etomidate and propofol inhibit the neurotransmitter release machinery at different sites. J Physiol. 2011 Mar 01; 589(Pt 5):1103-15.
PMID: 21173083

Isoflurane inhibits the neurotransmitter release machinery.
Herring BE, Xie Z, Marks J, Fox AP. Isoflurane inhibits the neurotransmitter release machinery. J Neurophysiol. 2009 Aug; 102(2):1265-73.
PMID: 19515956

A large collapsed-state RNA can exhibit simple exponential single-molecule dynamics.
Smith GJ, Lee KT, Qu X, Xie Z, Pesic J, Sosnick TR, Pan T, Scherer NF. A large collapsed-state RNA can exhibit simple exponential single-molecule dynamics. J Mol Biol. 2008 May 09; 378(4):943-53.
PMID: 18402978

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