Zheng Xie, MD PhD

Towards a potent and rapidly reversible Dexmedetomidine-based general anesthetic.
Towards a potent and rapidly reversible Dexmedetomidine-based general anesthetic. PLoS One. 2023; 18(9):e0291827.
PMID: 37751454

Rapid emergence from dexmedetomidine sedation in Sprague Dawley rats by repurposing an a2-adrenergic receptor competitive antagonist in combination with caffeine.
Rapid emergence from dexmedetomidine sedation in Sprague Dawley rats by repurposing an a2-adrenergic receptor competitive antagonist in combination with caffeine. BMC Anesthesiol. 2023 02 01; 23(1):39.
PMID: 36721095

Caffeine reverses the unconsciousness produced by light anesthesia in the continued presence of isoflurane in rats.
Caffeine reverses the unconsciousness produced by light anesthesia in the continued presence of isoflurane in rats. PLoS One. 2020; 15(11):e0241818.
PMID: 33152041

A pilot study showing that repeated exposure to stress produces alterations in subsequent responses to anesthetics in rats.
A pilot study showing that repeated exposure to stress produces alterations in subsequent responses to anesthetics in rats. PLoS One. 2019; 14(3):e0214093.
PMID: 30908509

Caffeine Accelerates Emergence from Isoflurane Anesthesia in Humans: A Randomized, Double-blind, Crossover Study.
Caffeine Accelerates Emergence from Isoflurane Anesthesia in Humans: A Randomized, Double-blind, Crossover Study. Anesthesiology. 2018 11; 129(5):912-920.
PMID: 30044241

Caffeine accelerates recovery from general anesthesia via multiple pathways.
Caffeine accelerates recovery from general anesthesia via multiple pathways. J Neurophysiol. 2017 09 01; 118(3):1591-1597.
PMID: 28659466

Caffeine accelerates recovery from general anesthesia.
Caffeine accelerates recovery from general anesthesia. J Neurophysiol. 2014 Mar; 111(6):1331-40.
PMID: 24375022

Interaction of anesthetics with neurotransmitter release machinery proteins.
Interaction of anesthetics with neurotransmitter release machinery proteins. J Neurophysiol. 2013 Feb; 109(3):758-67.
PMID: 23136341

Three-in-one nerve block with different concentrations of bupivacaine in total knee arthroplasty: randomized, placebo-controlled, double-blind trial.
Three-in-one nerve block with different concentrations of bupivacaine in total knee arthroplasty: randomized, placebo-controlled, double-blind trial. J Arthroplasty. 2012 May; 27(5):673-8.e1.
PMID: 21945081

Etomidate and propofol inhibit the neurotransmitter release machinery at different sites.
Etomidate and propofol inhibit the neurotransmitter release machinery at different sites. J Physiol. 2011 Mar 01; 589(Pt 5):1103-15.
PMID: 21173083